Penguin and Catwoman fall in love and team up to commit their biggest heist, stealing the world's vaccine supply and using it spread the vaccine across the world to inoculate everyone and end the global pandemic.
Believing that fear holds people back, Scarecrow tries to find a way to inspire ordinary people to overcome fear by finding the one person whom he believes to be fearless: Nightwing.
Poison Ivy uses fungal spores to infect employees at a chemical plant so that she can destroy the plant, but the spores have the effect of causing one employee to fall in love with Ivy.
A small-time criminal adopts the identity of to give him and his gang prestige and recognition. However, his gang feels that the additional recognition is not good for them and confront their leader about it.
Damian assists the police to help find the Mad Hatter, who is planning the theft of cutting edge technology from WayneTech.
Realizing he will never be one of the great villains, Killer Moth settles for being a fringe villain and living a life that makes him happy.
Ra's Al Ghul tests Batman in the past and in the present using a game of chess to evaluate his adversary.
Now the new leader of Leviathan, Talia reflects on her upbringing with her father.
- - Table of contents on the inside front cover.
Stories are listed in the table of contents in a different sequence than they appear in the issue.
- Bird Cat Love - Story is set in "another time, another place." It is not in continuity.
- Batcomputer Profile Designate: Scarecrow - Illustration taken from Batman: The Long Halloween (DC, 1996 series) #8.
- Batcomputer Profile Designate: Red Hood - Image is an homage to the cover of Detective Comics (DC, 1937 series) #168 by Lew Sayre Schwartz and George Roussos.
- For the Sky is Red - The villain Red Hood in this story is identified only as Hank. After his death, it is insinuated that someone else may adopt the Red Hood identity.
- The Perfect Fit - Mad Hatter's story continues in Arkham City: The Order of the World (DC, 2021 series) #1.
- Batcomputer Profile Designate: Killer Moth - Illustration taken from Batgirl Year One (DC, 2003 series) #5.
- The Second Eye - Story takes place after Checkmate (DC, 2021 series) #6.
- - Indicia and publisher information on the inside back cover.
- - Enlarged illustration from the front cover with a large DC logo and barcode.
